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Project Fields

 

We have defined three project fields in the Macedonian Human DNA Bank: anthropology (hDNAMKD1), unrelated patients (hDNAMKD2), and blood related patients (hDNAMKD3). Laboratory code for the DNA samples stored in Macedonian Human DNA Bank is MKDSPI (Table 1).

 

Table 1: Project Fields, hDNA Bank Code, and frequency of DNA samples stored in Macedonian Human DNA Bank (hDNAMKD)  (December, 2002).

 

Project field

hDNA Bank Code

DNA stored samples

2000

2001

2002

2000-2002

Anthropology

hDNAMKD1

46

279

653

978

Unrelated patients

hDNAMKD2

111

249

75

435

Related patients

hDNAMKD3

19

159

103

281

TOTAL

3

176

687

831

1694

 

 

 

 

Anthropology (hDNAMKD1)

 

Depositor of the DNA samples of anthropology project field is Foundation Macedonian Donor Registry (MKDR) with 594 deposited samples. The structure and definition of populations in this project (ANTH) are defined according to the personal national declaration, spoken language, and religion (Table 2).

Macedonians are defined as a nation with Macedonian origin, with Macedonian primary and secondary language, and with different religions (Orthodox, Catholic, Protestant, Muslims e.t.c.). National minorities (ethnicities) in the Republic of Macedonia are defined with MKD as a prefix added to the minority name. MKDAlbanians are Albanian minorities with Albanian as a primary language, Macedonian as a secondary language, and Muslim religion. MKDRoma are roma minorities with heterogeneous primary language (macedonian, Roma, and Turkish), with Macedonian secondary language, and with Muslim religion. MKDTurks are Turkish minorities with Turkish primary language, with Macedonian secondary language, and with muslim religion. MKDSerbs are serbs minorities with Serbian primary language, macedonian secondary language, and orthodox religion. MKDVlachs are vlachs minorities with vlachs primary language, macedonian secondary language, and orthodox religion. MKDAdmixed are the rest of minorities (Monte Negro, Jeush, and others) with admixed primary languages, and admixed religions. There are DNA samples from the Gora region, southwest Kosovo, Yugoslavia labeled as YUGGora with goran as a primary language, macedonian secondary language, and muslim religion. YUGGorans are very close to MKDMuslims situated in the west part of Republic of Macedonia (Table 2). The number of DNA samples in the Anthropology project field is continuously growing up.

 

 

Table 2: Definition of Macedonian population DNA samples stored in the Anthropology project field of Macedonian Human DNA Bank  (hDNAMKD1) (August, 2002).

 

 

Population Name (ethnicity)

Nation

Other Nation

Primary Language

Secondary (Home) Language

Religion

DNA Samples

Macedonians

Macedonian

Macedonian

Macedonian

Macedonian

Orthodox

Catholic

Protestant

Muslim

353

0

0

4

MKDAlbanians

Albanian

Macedonian

Albanian

Macedonian

Muslim

Catholic

50

0

MKDRoma

Roma

Macedonian

Roma

Macedonian

Turkish

Macedonian

Muslim

82

MKDTurks

Turk

Macedonian

Turkish

Macedonian

Muslim

8

MKDSerbs

Serb

Macedonian

Serbian

Macedonian

Orthodox

9

MKDValchs

Vlach

Macedonian

Vlachs

Macedonian

Orthodox

2

MKDAdmixed

Admixed

Macedonian

Admixed

Macedonian

Admixed

6

YUGGorans

Gora

Serbian

Macedonian

Serbian

Muslim

80

TOTAL

 

 

 

 

 

594

 

 

 

Unrelated patients (hDNAMKD2)

 

Depositors of the DNA samples included in clinical projects are medical doctors cooperating with the Foundation Macedonian Donor Registry (MKDR).  There are 10 projects focused on  different clinical diagnosis selected by depositor according defined criteria. The number of clinical projects and DNA samples is continuously growing up. Project codes for unrelated patients are defined as fore character codes. A total of 409 DNA samples from unrelated patients from different projects are stored in the DNA bank (Table 3).  

 

 

Table 3: DNA samples from the unrelated patients project field stored in Macedonian Human DNA Bank (hDNAMKD2)  (August, 2002).

 

 

Project Laboratory Code Project Code Depositor DNA samples
Rheumatoid Arthritis MKDSPI RHEU Prof. Dr. Snezhana Perchinkova, Clinic of Rheumatology, Faculty of Medicine, Skopje, MKD

79

Dilated Cardiomyopathies MKDSPI DILC Assist. Dr. Borka Petrovska, Institute of Heart Diseases, Faculty of Medicine, Skopje, MKD

58

Coronary Artery Disease MKDSPI CAD1 Assist. Prof. Dr. Sasho Kedev, Dr. Igor Spiroski, Institute of Heart Diseases, Faculty of Medicine, Skopje, MKD

44

Tuberculosis MKDSPI TBC1 Assist. Dr. Mirjana Trajchevska, Institute of Pulmonary Tuberculosis, Skopje, MKD

75

Diabetes Mellitus Type 1 MKDSPI DM01 Prof. Dr. Chedo Dimitrovski, Clinic for Endocrinology and Metabolic Diseases, Faculty of Medicine, Skopje, MKD

10

Diabetes Mellitus Type 2 MKDSPI DM02 Prof. Dr. Chedo Dimitrovski, Clinic for Endocrinology and Metabolic Diseases, Faculty of Medicine, Skopje, MKD

98

Asthma MKDSPI ASTH Prof. Dr. Angjelko Gjorchev, Clinic for Pulmoallergology, Faculty of Medicine, Skopje, MKD

22

Psoriasis MKDSPI PSOR Assist. Dr. Nina Caca-Biljanovska, Clinic for Dermatovenerology, Faculty of Medicine, Skopje, MKD

13

Thrombosis MKDSPI THRO Prof. Dr. Stojanka Kostovska, Republic Department of Transfuziology, Skopje, MKD

6

Immune Deficiencies MKDSPI IMMD Assist. Prof. Dr. Sonja Peova, Clinic for Pediatrics, Faculty of Medicine, Skopje, MKD

4

TOTAL  

10

 

409

 

 

 

 

 

Blood related patients (hDNAMKD3)

 

We have three projects which include family data: related bone marrow transplantation (BMTR), related renal transplantation (RETR), and autism (AUTI) consisted of 67 families with a total of 232 persons (DNA samples). Depositors are medical doctors connected with particular project. The number of projects, families, and DNA samples from blood related samples is in continuous progress (Table 4).

 

 

Table 4: DNA samples from related patients project field stored in Macedonian Human DNA Bank (hDNAMKD3)  (August, 2002).

 

 
Project Laboratory Code Project Code Cooperation Families DNA samples
Related Bone Marrow Transplantation MKDSPI BMTR Assist. Prof. Dr. Dimitar Efremov, Clinic of Haematology, Faculty of Medicine, Skopje, MKD

31

122

Related Renal Transplantation MKDSPI RETR Prof. Dr. Ninoslav Ivanovski, Clinic of Nephrology, Faculty of Medicine, Skopje, MKD

2

4

Autism MKDSPI AUTI Assist. Dr. Vladimir Trajkovski, Institute of Special Education and Rehabilitation, Faculty of Philosophy, Skopje, MKD

34

106

TOTAL  

3

 

67

232

 


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Update: October, 2013
Author: Mirko Spiroski, MD, PhD
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