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Project Fields

We have defined three project fields in the Macedonian Human DNA Bank: anthropology (hDNAMKD1), unrelated patients (hDNAMKD2), and blood related patients (hDNAMKD3). Laboratory code for the DNA samples stored in Macedonian Human DNA Bank is MKDSPI (Table 1).

Table 1: Project Fields, hDNA Bank Code, and frequency of DNA samples stored in Macedonian Human DNA Bank (hDNAMKD)  (December, 2002).

Anthropology (hDNAMKD1)

Depositor of the DNA samples of anthropology project field is Foundation Macedonian Donor Registry (MKDR) with 594 deposited samples. The structure and definition of populations in this project (ANTH) are defined according to the personal national declaration, spoken language, and religion (Table 2).

Macedonians are defined as a nation with Macedonian origin, with Macedonian primary and secondary language, and with different religions (Orthodox, Catholic, Protestant, Muslims e.t.c.). National minorities (ethnicities) in the Republic of Macedonia are defined with MKD as a prefix added to the minority name. MKDAlbanians are Albanian minorities with Albanian as a primary language, Macedonian as a secondary language, and Muslim religion. MKDRoma are roma minorities with heterogeneous primary language (macedonian, Roma, and Turkish), with Macedonian secondary language, and with Muslim religion. MKDTurks are Turkish minorities with Turkish primary language, with Macedonian secondary language, and with muslim religion. MKDSerbs are serbs minorities with Serbian primary language, macedonian secondary language, and orthodox religion. MKDVlachs are vlachs minorities with vlachs primary language, macedonian secondary language, and orthodox religion. MKDAdmixed are the rest of minorities (Monte Negro, Jeush, and others) with admixed primary languages, and admixed religions. There are DNA samples from the Gora region, southwest Kosovo, Yugoslavia labeled as YUGGora with goran as a primary language, macedonian secondary language, and muslim religion. YUGGorans are very close to MKDMuslims situated in the west part of Republic of Macedonia (Table 2). The number of DNA samples in the Anthropology project field is continuously growing up.

Table 2: Definition of Macedonian population DNA samples stored in the Anthropology project field of Macedonian Human DNA Bank  (hDNAMKD1) (August, 2002).

Unrelated patients (hDNAMKD2)

Depositors of the DNA samples included in clinical projects are medical doctors cooperating with the Foundation Macedonian Donor Registry (MKDR).  There are 10 projects focused on  different clinical diagnosis selected by depositor according defined criteria. The number of clinical projects and DNA samples is continuously growing up. Project codes for unrelated patients are defined as fore character codes. A total of 409 DNA samples from unrelated patients from different projects are stored in the DNA bank (Table 3).  

Table 3: DNA samples from the unrelated patients project field stored in Macedonian Human DNA Bank (hDNAMKD2)  (August, 2002).

Blood related patients (hDNAMKD3)

We have three projects which include family data: related bone marrow transplantation (BMTR), related renal transplantation (RETR), and autism (AUTI) consisted of 67 families with a total of 232 persons (DNA samples). Depositors are medical doctors connected with particular project. The number of projects, families, and DNA samples from blood related samples is in continuous progress (Table 4).

Table 4: DNA samples from related patients project field stored in Macedonian Human DNA Bank (hDNAMKD3)  (August, 2002).

 

Project	Laboratory Code	Project Code	Cooperation	Families	DNA samples
Related Bone Marrow Transplantation	MKDSPI	BMTR	Assist. Prof. Dr. Dimitar Efremov, Clinic of Haematology, Faculty of Medicine, Skopje, MKD	31	122
Related Renal Transplantation	MKDSPI	RETR	Prof. Dr. Ninoslav Ivanovski, Clinic of Nephrology, Faculty of Medicine, Skopje, MKD	2	4
Autism	MKDSPI	AUTI	Assist. Dr. Vladimir Trajkovski, Institute of Special Education and Rehabilitation, Faculty of Philosophy, Skopje, MKD	34	106
TOTAL		3		67	232

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Update: October, 2013
Author: Mirko Spiroski, MD, PhD
Hosted by: MCMS, Skopje